Anticorps TFIIIC102 (X-421): sc-101176
- L'Anticorps TFIIIC102 (X-421) est un monoclonal de souris IgG2b κ, cité dans 1 publications, fourni en 50 µg/0.5 ml
- dirigé contre la TFIIIC102 recombinante d'origine human
- recommandé pour la détection de TFIIIC102 d'origine mouse, rat et human par WB, IP et ELISA
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire TFIIIC102 (X-421). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB″, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TFIIIC102 (X-421) | sc-101176 | 50 µg/0.5 ml | $333.00 |