TFIIIC102 Antibody (C-2): sc-393235
- TFIIIC102 Antibody (C-2) is a mouse monoclonal IgG1 κ TFIIIC102 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 126-413 mapping within an internal region of TFIIIC102 of human origin
- TFIIIC102 Antibody (C-2) is recommended for detection of TFIIIC102 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TFIIIC102 Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-393235 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TFIIIC102 Antibody (C-2) for WB applications. These reagents are now offered in bundles with TFIIIC102 Antibody (C-2) (see ordering information below).
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TFIIIC102 Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects TFIIIC102 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TFIIIC102 (C-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TFIIIC102 plays a crucial role in the transcription of genes by RNA polymerase III, which is responsible for synthesizing essential small RNAs such as tRNA and 5S rRNA. This function is particularly important because proper regulation of RNA polymerase III activity is vital for cellular growth and proliferation; overexpression of TFIIIC102 has been observed in various transformed cell lines and tumors, indicating a potential role in cancer biology. The TFIIIC2 complex, which includes TFIIIC102 along with other subunits, is essential for recruiting RNA polymerase III to promoter elements, thereby facilitating transcription of genes necessary for rapid cell division. In many malignant cells, deregulation of this complex can lead to uncontrolled growth, making TFIIIC102 a significant target for research into cancer therapies and diagnostics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TFIIIC102 Antibody (C-2) References:
- The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. | Hsieh, YJ., et al. 1999. Mol Cell Biol. 19: 7697-704. PMID: 10523658
- Interactions between the tetratricopeptide repeat-containing transcription factor TFIIIC131 and its ligand, TFIIIB70. Evidence for a conformational change in the complex. | Moir, RD., et al. 2000. J Biol Chem. 275: 26591-8. PMID: 10859316
- Alternatively spliced hBRF variants function at different RNA polymerase III promoters. | McCulloch, V., et al. 2000. EMBO J. 19: 4134-43. PMID: 10921893
- Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. | Schramm, L., et al. 2000. Genes Dev. 14: 2650-63. PMID: 11040218
- RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors. | Winter, AG., et al. 2000. Proc Natl Acad Sci U S A. 97: 12619-24. PMID: 11058163
- Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription. | Sutcliffe, JE., et al. 2000. Mol Cell Biol. 20: 9192-202. PMID: 11094071
- RNA polymerase III transcription: its control by tumor suppressors and its deregulation by transforming agents. | Brown, TR., et al. 2000. Gene Expr. 9: 15-28. PMID: 11097422
- Activation of mouse genes in transformed cells. | Scott, MR., et al. 1983. Cell. 34: 557-67. PMID: 6311432
- Expression of neural BC1 RNA: induction in murine tumours. | Chen, W., et al. 1997. Eur J Cancer. 33: 288-92. PMID: 9135502
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFIIIC102 Antibody (C-2) | sc-393235 | 200 µg/ml | $322.00 | |||
TFIIIC102 Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-530398 | 200 µg Ab; 10 µg BP | $361.00 | |||
TFIIIC102 Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-523864 | 200 µg Ab, 40 µg BP | $361.00 | |||
TFIIIC102 Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-544032 | 200 µg Ab; 20 µg BP | $361.00 | |||
TFIIIC102 Antibody (C-2) X | sc-393235 X | 200 µg/0.1 ml | $322.00 | |||
TFIIIC102 Antibody (C-2) AC | sc-393235 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TFIIIC102 Antibody (C-2) HRP | sc-393235 HRP | 200 µg/ml | $322.00 | |||
TFIIIC102 Antibody (C-2) FITC | sc-393235 FITC | 200 µg/ml | $336.00 | |||
TFIIIC102 Antibody (C-2) PE | sc-393235 PE | 200 µg/ml | $349.00 | |||
TFIIIC102 Antibody (C-2) Alexa Fluor® 488 | sc-393235 AF488 | 200 µg/ml | $364.00 | |||
TFIIIC102 Antibody (C-2) Alexa Fluor® 546 | sc-393235 AF546 | 200 µg/ml | $364.00 | |||
TFIIIC102 Antibody (C-2) Alexa Fluor® 594 | sc-393235 AF594 | 200 µg/ml | $364.00 | |||
TFIIIC102 Antibody (C-2) Alexa Fluor® 647 | sc-393235 AF647 | 200 µg/ml | $364.00 | |||
TFIIIC102 Antibody (C-2) Alexa Fluor® 680 | sc-393235 AF680 | 200 µg/ml | $364.00 | |||
TFIIIC102 Antibody (C-2) Alexa Fluor® 790 | sc-393235 AF790 | 200 µg/ml | $364.00 |