Anticorps TAB182 (G-5): sc-514490

Tankyrase-1 and -2 are closely related poly(ADP-ribose) polymerases that colocalize and use an ankyrin-repeat domain to bind diverse proteins, including TRF-1 (telomere-repeat-binding factor 1), IRAP (insulin-responsive aminopeptidase), and TAB182. Tankyrase-1 and Tankyrase-2 mediate overlapping functions, both at telomeres and in vesicular compartments. TAB182 is a Tankyrase binding protein which not only binds to the ANK repeat domain of Tankyrase-1 and Tankyrase-2, but also serves as an acceptor of poly(ADP-ribosyl)ation by Tankyrase-1. TAB182 is expressed in multiple tissues such as the kidney, pancreas, heart, lung, liver, and ovary, as well as the brain and peripheral blood leukocytes, to a lesser extent. The TAB182 protein localizes to nucleus and to the cytoplasm, where it colocalizes with the cortical actin network. Two basic regions at the N-terminal and C-terminal domains of TAB182 and a large internal acidic region comprise TAB182. The C-terminal domain also contains 2 possible nuclear localization signals.

L'anticorps TAB182 préféré est l'Anticorps TAB182 (D-5): sc-514517.