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Smad proteins play an important role in the intracellular signalling of the TGFβ superfamily of extracellular polypeptides. Two Smad proteins, Smad6 and Smad7, function as antagonists to TGFβ signalling. STRAP, another antagonist to the TGFβ signalling pathway, specifically interacts with Smad7, but not Smad6, to synergistically block TGFβ-induced transcriptional activation. The gene encoding the human homolog of STRAP (as designated in mouse), called unr-interacting protein, maps to chromosome 12p12.3. Unr-interacting protein is 97% homologous to STRAP at the amino acid level. The unr-interacting protein binds unr, a cytoplasmic RNA-binding protein with five cold-shock domains that is involved in RNA translation. The presence of the STRAP gene in a variety of species from mammals to yeast, indicates that STRAP function is evolutionarily conserved in eukaryotic cells.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps STRAP (3G6) | sc-130671 | 200 µg/ml | $316.00 | |||
STRAP (3G6): m-IgG Fc BP-HRP Kit | sc-539837 | 200 µg Ab; 10 µg BP | $354.00 |