SPT6 (suppressor of Ty6 homolog), also known as SUPT6H, SPT6H, Tat-CT2 (Tat-cotransactivator 2 protein) or emb-5 in C. elegans, is a 1,726 amino acid protein that is highly conserved from yeast to humans. Expressed ubiquitously, SPT6 localizes to the nucleus and contains one SH2 domain and one S1 domain. SPT6 participates in both DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole)-mediated transcriptional inhibition as well as the enhancement of transcriptional elongation by the RNA polymerase II (Pol II). SPT6 interacts with the nuclear proteins SPT4 and SPT5, which comprise the DSIF (DRB-sensitivity-inducing factor) complex that binds RNA polymerase II, and directly regulates elongation. Via its C-terminus, SPT6 can also interact with Histone H3. Due to alternative splicing events, three isoforms exist for SPT6.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SPT6 (C-6) | sc-393938 | 200 µg/ml | $316.00 | |||
SPT6 (C-6): m-IgG Fc BP-HRP Kit | sc-538339 | 200 µg Ab; 10 µg BP | $354.00 | |||
SPT6 (C-6): m-IgGκ BP-HRP Kit | sc-535930 | 200 µg Ab; 40 µg BP | $354.00 | |||
SPT6 (C-6): m-IgG2a BP-HRP Kit | sc-548274 | 200 µg Ab; 10 µg BP | $354.00 |