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Sp110 (Speckled 110 kDa), also known as IPR1, VODI, IFI41 (interferon-induced protein 41, 30 kDa) or IFI75 (interferon-induced protein 75, 52 kDa), is a phosphoprotein belonging to the SP-100/SP140 family of nuclear body components. Sp110 contains an HSR domain, a PHD-type zinc finger, a SAND domain and a bromodomain and is believed to function as a transcriptional coactivator of nuclear hormone receptors. Induced by IFN-g and all-trans retinoic acid, Sp110 participates in immunoprotective mechanisms against pathogens. Mutations in the gene encoding SP110 can lead to hepatic venoocclusive disease with immunodeficiency (VODI), a disease characterized by T and B cell immunodeficiency, absent tissue plasma cells, absent lymph node germinal centers and severe hypogammaglobulinemia. Due to alternative splicing events, five isoforms exist for Sp110. Isoform 3, also known as Sp110b, interacts with the Hep C Core Protein.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Sp110 (JR-16) | sc-100770 | 100 µg/ml | $333.00 |