Septins are members of a conserved family of cytoskeletal GTPases, specifically belonging to the large superclass of P-loop GTPases. Septin proteins form homo- and hetero-oligomeric polymers that accumulate into higher-order filaments which may function as dynamic protein scaffolds. Septins play an important role in vesicle trafficking, apoptosis, cytoskeleton remodeling, infection, neurodegeneration, neoplasia and cytokinesis. Septin 8 is a 508 amino acid protein that is expressed in the brain, cardiovascular regions, prostate, testis and ovary. Septin 8 interacts with both Septin 5 and cell division cycle related-1 (CDCrel-1). Septin 8 may play an important role in the functional regulation of hPFTAIRE1, a member of the Cdc2-related kinase family that is localized in cytoplasm. Septin 8, Septin 4 and Septin 5 surround a-granules, implicating these three septins as components of the septin complex in platelets and contributing to platelet biology.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Septin 8 (D-7) | sc-390105 | 200 µg/ml | $316.00 | |||
Septin 8 (D-7): m-IgG2a BP-HRP Kit | sc-546069 | 200 µg Ab; 10 µg BP | $354.00 | |||
Septin 8 (D-7) peptide neutralisant | sc-390105 P | 100 µg/0.5 ml | $68.00 |