ACCÈS RAPIDE AUX LIENS
The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3), and belongs to the acute myeloid leukemia (AML) family. RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX3 is expressed in cells of hematopoietic origin, including myeloid and B-cell lines and spleen. By playing a role in controlling the growth and differentiation of gastric epithelial cells, RUNX3 is a strong candidate as a gastric cancer tumor suppressor. Specifically, hypermethylation inactivates the gene encoding RUNX3. The detection of hypermethylation at multiple regions within the RUNX3 CpG island may aid in the diagnosis and risk assessment of gastric cancer.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RUNX3 (B-9) | sc-376543 | 200 µg/ml | $316.00 | |||
RUNX3 (B-9): m-IgG Fc BP-HRP Kit | sc-540596 | 200 µg Ab; 10 µg BP | $354.00 | |||
RUNX3 (B-9): m-IgG1 BP-HRP Kit | sc-542231 | 200 µg Ab; 20 µg BP | $354.00 | |||
Anticorps RUNX3 (B-9) X | sc-376543 X | 200 µg/0.1 ml | $316.00 |