ACCÈS RAPIDE AUX LIENS
RUFY1 (RUN and FYVE domain containing 1), also known as RABIP4 or ZFYVE12, is a 708 amino acid protein that localizes to the cytoplasm and the early endosome membrane. Highly expressed in testis, lung, brain and kidney, RUFY1 functions to bind phosphatidylinositol 3-phosphate-containing phospholipid vesicles and, via this interaction, participates in early endosomal trafficking. RUFY1 contains one RUN domain and one FYVE-type zinc finger through which it mediates its ability to bind phosphatidylinositol 3-phosphate. Upon DNA damage, RUFY1 may be phosphorylated by ATM or ATR. Additionally, the phosphorylation of Tyr 389 and/or Tyr 400 residues on human RUFY1 is thought to be necessary for endosomal localization. Three isoforms of RUFY1 exist due to alternative splicing events.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RUFY1 (SS-41) | sc-100846 | 100 µg/ml | $333.00 |