

ACCÈS RAPIDE AUX LIENS
RUFY1 (RUN and FYVE domain containing 1), also known as RABIP4 or ZFYVE12, is a 708 amino acid protein that localizes to the cytoplasm and the early endosome membrane. Highly expressed in testis, lung, brain and kidney, RUFY1 functions to bind phosphatidylinositol 3-phosphate-containing phospholipid vesicles and, via this interaction, participates in early endosomal trafficking. RUFY1 contains one RUN domain and one FYVE-type zinc finger through which it mediates its ability to bind phosphatidylinositol 3-phosphate. Upon DNA damage, RUFY1 may be phosphorylated by ATM or ATR. Additionally, the phosphorylation of Tyr 389 and/or Tyr 400 residues on human RUFY1 is thought to be necessary for endosomal localization. Three isoforms of RUFY1 exist due to alternative splicing events.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RUFY1 (SS-41) | sc-100846 | 100 µg/ml | $333.00 |