Anticorps Rent2 (G-9): sc-398812
- Rent2 anticorps (G-9) est un monoclonal de souris IgG2a (chaîne légère lambda) fourni en 200 µg/ml
- spécifique d'un épitope situé entre les acides aminés 1247-1273 près de C-terminus de Rent2 d'origine human
- recommandé pour la détection de Rent2 d'origine mouse, rat et human par WB, IP, IF et ELISA
- m-IgG Fc BP-HRP et 2a BP-HRP">m-IgG2a BP-HRP sont les réactifs de détection secondaire préférés pour Rent2 Antibody (G-9) pour les applications WB. Ces réactifs sont désormais proposés en lots avec Rent2 Antibody (G-9)(voir les informations de commande ci-dessous).
In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability. Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase. Rent1 protein has nucleic-acid-dependent ATPase activity and 5' to 3' helicase activity. In addition, Rent1 is an RNA-binding protein whose activity is modulated by ATP and directly interacts with Rent2, which is a mammalian homolog of Upf2p. Two mammalian orthologs to Upf3p, Rent3a and Rent3b, are encoded by two separate genes. Rent3b (also known as Rent3X) is encoded by a X-linked gene and localizes primarily to the nucleus, while Rent 1 and Rent 2 localize primarily in the cytoplasm. Specific Rent3 protein interactions with Y14 and spliced mRNA suggest Rent3a and Rent3b serve as a link between splicing and NMD in the cytoplasm.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Rent2 (G-9) | sc-398812 | 200 µg/ml | $316.00 | |||
Rent2 (G-9): m-IgG Fc BP-HRP Kit | sc-540947 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rent2 (G-9): m-IgG2a BP-HRP Kit | sc-546986 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rent2 (G-9) peptide neutralisant | sc-398812 P | 100 µg/0.5 ml | $68.00 |