RelB Antibody (C-4): sc-48379
- RelB Antibody (C-4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 380-579 of RelB of human origin
- recommended for detection of RelB of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See RelB (D-4): sc-48366 for RelB antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for RelB Antibody (C-4) for WB and IHC(P) applications. This reagent is now offered in a bundle with RelB Antibody (C-4) (see ordering information below).
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RelB Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects RelB in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RelB is a crucial member of the NFκB family of transcription factors, playing a significant role in regulating immune responses, inflammation, and cell survival. anti-RelB antibody (C-4) forms heterodimers with other NFκB subunits, such as p50, to bind to specific DNA sequences and activate transcription of target genes in the nucleus. This nuclear localization allows RelB to exert effects on gene expression in response to various stimuli, including cytokines and stress signals. Additionally, RelB undergoes post-translational modifications, such as phosphorylation, which can influence activity and stability, further underscoring importance in cellular signaling pathways. RelB (C-4) antibody serves as an essential tool for researchers studying NFκB signaling in health and disease, providing insights into function in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RelB Antibody (C-4) References:
- The role of relB in regulating the adaptive immune response. | Zanetti, M., et al. 2003. Ann N Y Acad Sci. 987: 249-57. PMID: 12727647
- Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions. | Baud, V. and Collares, D. 2016. Cells. 5: PMID: 27153093
- RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis. | Shen, F., et al. 2018. Oncol Lett. 15: 4404-4410. PMID: 29541209
- RelB intrinsically regulates the development and function of medullary thymic epithelial cells. | Jin, C. and Zhu, M. 2018. Sci China Life Sci. 61: 1039-1048. PMID: 29730722
- Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice. | Elßner, C., et al. 2019. Gastroenterology. 156: 1190-1205.e14. PMID: 30445013
- RelB controls adaptive responses of astrocytes during sterile inflammation. | Gupta, AS., et al. 2019. Glia. 67: 1449-1461. PMID: 30957303
- RelB sustains endocrine resistant malignancy: an insight of noncanonical NF-κB pathway into breast Cancer progression. | Wang, M., et al. 2020. Cell Commun Signal. 18: 128. PMID: 32807176
- The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma. | Eluard, B., et al. 2022. Blood. 139: 384-398. PMID: 34232979
- RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro. | Li, W., et al. 2022. Cell Signal. 91: 110221. PMID: 34933092
- RelB, a member of the Rel/NF-kappa B family of transcription factors. | Ryseck, RP., et al. 1996. Braz J Med Biol Res. 29: 895-903. PMID: 9070378
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RelB Antibody (C-4) | sc-48379 | 200 µg/ml | $322.00 | |||
RelB Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-538938 | 200 µg Ab; 10 µg BP | $361.00 |