RelB Inhibitors
The RelB inhibitors class encompasses a range of chemical compounds designed to selectively modulate the activity of the NF-κB subunit, RelB. These inhibitors impact both the canonical and noncanonical NF-κB pathways, disrupting the formation of RelB-containing complexes and subsequent downstream signaling cascades. Dehydroxymethylepoxyquinomicin, CDDO-Im, DHMEQ, Bay 11-7082, Celastrol, TDZD-8, Quinacrine, Andrographolide, JSH-23, Parthenolide, Triptolide, and Wedelolactone form a toolkit of RelB inhibitors. These chemicals offer researchers valuable resources to delve into the specific contributions of RelB to cellular processes, inflammation, immune responses, and cancer. Despite their inhibitory effects, the precise mechanisms and conditions governing the modulation of RelB activity by these compounds remain subjects of ongoing investigation. The toolkit provides researchers with the means to explore nuanced interactions within NF-κB signaling dynamics and to decipher the regulatory roles of RelB in diverse biological contexts.
Dehydroxymethylepoxyquinomicin, a synthetic compound, offers researchers a tool to dissect the specific contributions of RelB to cellular processes, with a focus on immunity, inflammation, and cancer. Similarly, CDDO-Im, a synthetic triterpenoid, and DHMEQ, a synthetic compound, present opportunities to explore the implications of RelB inhibition in various biological contexts. Bay 11-7082, a synthetic compound known for its inhibitory effects on NF-κB, including RelB, serves as a versatile tool for investigating the role of RelB in inflammation, immune responses, and cancer. Celastrol, a natural triterpenoid, TDZD-8, a synthetic compound, and Quinacrine, a synthetic compound, broaden the spectrum of RelB inhibitors, each offering unique insights into the nuanced regulatory functions of RelB. Furthermore, Andrographolide, a natural compound, JSH-23, a synthetic compound, and Parthenolide, a natural compound, contribute to the toolkit, providing researchers with additional options to explore the multifaceted roles of RelB in different biological scenarios. Triptolide, a natural compound, and Wedelolactone, another natural compound, round out the toolkit, adding to the array of RelB inhibitors available for in-depth investigations.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CDDO Imidazolide | 443104-02-7 | sc-504719 | 1 mg | $700.00 | ||
CDDO-Im, a synthetic triterpenoid, exhibits inhibitory effects on RelB and NF-κB signaling. Its potential as a RelB inhibitor suggests interference with the formation of RelB-containing complexes. CDDO-Im provides researchers with a pharmacological tool to dissect the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 is a synthetic compound known for its inhibitory effects on NF-κB, including the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. Bay 11-7082 provides researchers with a tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol, a natural triterpenoid, exhibits inhibitory effects on NF-κB, including the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. Celastrol provides researchers with a pharmacological tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
GSK-3β Inhibitor I | 327036-89-5 | sc-221692 sc-221692A | 5 mg 25 mg | $183.00 $288.00 | 4 | |
TDZD-8 is a synthetic compound with reported inhibitory effects on NF-κB, potentially including the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. TDZD-8 provides researchers with a pharmacological tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
Quinacrine, Dihydrochloride | 69-05-6 | sc-204222 sc-204222B sc-204222A sc-204222C sc-204222D | 100 mg 1 g 5 g 200 g 300 g | $46.00 $57.00 $87.00 $3257.00 $4821.00 | 4 | |
Quinacrine, a synthetic compound, exhibits inhibitory effects on NF-κB, potentially affecting the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. Quinacrine provides researchers with a pharmacological tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide, a natural compound, exhibits inhibitory effects on NF-κB, potentially affecting the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. Andrographolide provides researchers with a pharmacological tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
JSH-23 is a synthetic compound known for its inhibitory effects on NF-κB, including the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. JSH-23 provides researchers with a tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide, a natural compound, exhibits inhibitory effects on NF-κB, potentially affecting the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. Parthenolide provides researchers with a pharmacological tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide, a natural compound, exhibits inhibitory effects on NF-κB, potentially affecting the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. Triptolide provides researchers with a pharmacological tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $110.00 $337.00 | 8 | |
Wedelolactone, a natural compound, exhibits inhibitory effects on NF-κB, potentially affecting the RelB subunit. Its potential as a RelB inhibitor suggests interference with the canonical and noncanonical NF-κB pathways. Wedelolactone provides researchers with a pharmacological tool to investigate the specific contributions of RelB to cellular processes and to explore its role in inflammation, immune response, and cancer. | ||||||