RCC1 Antibody (H-5): sc-376715

RCC1 Antibody (H-5) is a mouse monoclonal IgG3 antibody that detects RCC1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RCC1, or regulator of chromosome condensation 1, plays a crucial role in the regulation of the small Ras-related protein Ran, which is essential for various cellular processes, including DNA replication and the transport of RNA and proteins through the nuclear pore complex. The function of RCC1 as a guanine nucleotide exchange factor is vital, as RCC1 facilitates the conversion of inactive Ran GDP to its active form, Ran GTP, thereby influencing the dynamics of nuclear transport and cell cycle progression. This regulation is particularly important during mitosis, where proper localization and activity of Ran are necessary for chromosomal stability and successful completion of cell division. By modulating Ran GTP levels, RCC1 ensures cellular processes are executed efficiently, highlighting RCC1′s significance in maintaining cellular homeostasis and function. Anti-RCC1 antibody (H-5) is an invaluable tool for researchers studying these critical pathways and their implications in cellular biology.

The preferred RCC1 antibody is RCC1 Antibody (E-6): sc-55559.