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Op18 (for oncoprotein 18, also designated Stathmin, prosolin or metablastin) is a conserved, tubulin-associated, intracellular protein. It serves as a transducing protein, via phosphorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation. Op18 is present in many cancers, including breast carcinoma and different leukemias. The neuronal growth-associated protein (nGAP) Stathmin-2, which shares sequence homology with the phosphoprotein Op18/Stathmin-1, is expressed in a variety of neural, immune and reproductive system cell types. Stathmin-2 gene expression is altered in age-related neurodegenerative diseases such as Alzheimer's disease. Stathmin-4 (also designated Stathmin-like protein B3 or RB3) is a Stathmin-like protein involved in the destabilization of microtubules, specifically in brain tissue. RB3 has a unique N-terminal membrane-associated domain and a Stathmin-like domain at the C-terminus. This C-terminal domain promotes microtubule destabilization and tubulin sequestering.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RB3 (C-9) | sc-374209 | 200 µg/ml | $316.00 | |||
RB3 (C-9): m-IgGκ BP-HRP Kit | sc-535419 | 200 µg Ab; 40 µg BP | $354.00 | |||
RB3 (C-9): m-IgG2b BP-HRP Kit | sc-549414 | 200 µg Ab; 10 µg BP | $354.00 | |||
RB3 (C-9) peptide neutralisant | sc-374209 P | 100 µg/0.5 ml | $68.00 |