PTTG Antibody (3F313): sc-71947
- PTTG Antibody (3F313) is a mouse monoclonal IgG2a, cited in 2 publications, provided at 200 µg/ml
- raised against full length PTTG of human origin
- recommended for detection of PTTG of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See PTTG (DCS-280): sc-56207 for PTTG antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP is the preferred secondary detection reagent for PTTG Antibody (3F313) for WB and IHC(P) applications. This reagent is now offered in a bundle with PTTG Antibody (3F313) (see ordering information below).
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PTTG Antibody (3F313) is a mouse monoclonal IgG2a antibody that detects pituitary tumor transforming gene (PTTG) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PTTG plays a crucial role in cell cycle regulation by acting as an anaphase inhibitor, specifically regulating separin Esp1, which is essential for chromatid separation during mitosis. This function helps ensure proper chromosome segregation, thereby preventing chromosomal instability, a hallmark of many cancers. PTTG expression has been observed in various human tissues, including thymus, testis, and placenta, with primary localization in cytoplasm and partial presence in nucleus, underscoring PTTG′s importance in cellular processes. PTTG′s interaction with other proteins involved in cell cycle regulation highlights anti-PTTG antibody (3F313) as an invaluable tool for scientists studying tumorigenesis and chromosomal dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PTTG Antibody (3F313) References:
- Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging. | Yu, R., et al. 2000. Mol Endocrinol. 14: 1137-46. PMID: 10935539
- PTTG/securin activates expression of p53 and modulates its function. | Hamid, T. and Kakar, SS. 2004. Mol Cancer. 3: 18. PMID: 15242522
- Suppression of lung cancer with siRNA targeting PTTG. | Kakar, SS. and Malik, MT. 2006. Int J Oncol. 29: 387-95. PMID: 16820881
- PTTG and PBF repress the human sodium iodide symporter. | Boelaert, K., et al. 2007. Oncogene. 26: 4344-56. PMID: 17297475
- PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines. | Minematsu, T., et al. 2007. Endocr Pathol. 18: 8-15. PMID: 17652795
- PTTG: an important target gene for ovarian cancer therapy. | Panguluri, SK., et al. 2008. J Ovarian Res. 1: 6. PMID: 19014669
- Immunohistochemical expression of PTTG in brain tumors. | Salehi, F., et al. 2013. Anticancer Res. 33: 119-22. PMID: 23267136
- PTTG promotes invasion in human breast cancer cell line by upregulating EMMPRIN via FAK/Akt/mTOR signaling. | Gao, H., et al. 2016. Am J Cancer Res. 6: 425-39. PMID: 27186413
- PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer. | Read, ML., et al. 2018. Cancer Res. 78: 5863-5876. PMID: 30154144
- Erratum: PTTG promotes invasion in human breast cancer cell line by upregulating EMMPRIN via FAK/Akt/mTOR signaling. | Gao, H., et al. 2020. Am J Cancer Res. 10: 1274-1276. PMID: 32368402
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTTG Antibody (3F313) | sc-71947 | 200 µg/ml | $322.00 | |||
PTTG Antibody (3F313): m-IgG2a BP-HRP Bundle | sc-546005 | 200 µg Ab; 10 µg BP | $361.00 |