PTH Antibody (D1.1): sc-57419
- PTH Antibody (D1.1) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 53-84 of PTH of human origin
- recommended for detection of PTH peptides (aa 53-68; 53-84; 7-84; and 1-84) of human, bovine and canine origin by WB, IP, IF and IHC(P); non cross-reactive with synthetic Parathyroid hormone peptides (aa 1-10; 1-34; 1-38)
- See PTH/PTHrP-R (3D1.1): sc-12722 for PTH antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PTH Antibody (D1.1). This work is in progress.
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PTH Antibody (D1.1) is a mouse monoclonal IgG1 antibody that detects parathyroid hormone (PTH) in human, bovine, and canine samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-PTH antibody (D1.1) enables research into PTH, a crucial 84 amino acid peptide that plays a vital role in regulating calcium metabolism by increasing blood calcium levels through multiple mechanisms, such as stimulating bone formation, which enhances bone mass and strength in both rats and humans. The first 34 amino acids at the amino terminus of the PTH molecule are particularly important for biological activity, highlighting the significance of this region in function. The gene encoding PTH is located on human chromosome 11p15.3-p15.1, and is essential for maintaining calcium homeostasis in the body. Additionally, parathyroid hormone-related protein (PTH-rP), which shares structural similarities with PTH, is synthesized by various cell types and plays a role in endochondral bone development and epithelial-mesenchymal interactions, particularly during mammary gland and tooth formation. Both PTH and PTH-rP are regulated by vitamin D and steroid hormones, and preferentially bind to specific PTH/PTH-rP receptors, activating signaling pathways that are critical for calcium regulation. PTH (D1.1) monoclonal antibody serves as an invaluable tool for researchers studying calcium metabolism and related disorders, providing insights into the physiological and pathological roles of this important hormone.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTH Antibody (D1.1) | sc-57419 | 100 µg/ml | $322.00 |