PTH Antibody (5E745): sc-71944
- PTH Antibody (5E745) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 53-84 of PTH of human origin
- recommended for detection of PTH peptides (aa 53-68; 53-84; 7-84; and 1-84) of human, bovine and canine origin by WB, IP, IF and IHC(P); non cross-reactive with synthetic Parathyroid hormone peptides (aa 1-10; 1-34; 1-38)
- See PTH/PTHrP-R (3D1.1): sc-12722 for PTH antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PTH Antibody (5E745). This work is in progress.
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PTH Antibody (5E745) is a mouse monoclonal IgG1 antibody that detects parathyroid hormone (PTH) in human, bovine, and canine samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PTH is a crucial 84 amino acid peptide that plays a vital role in regulating calcium metabolism by increasing blood calcium levels through multiple mechanisms, such as stimulating bone formation, which enhances bone mass and strength in both rats and humans. Notably, the first 34 amino acids at the amino terminus of the PTH molecule are essential for its biological activity, highlighting the importance of this region in its function. The gene encoding PTH is located on human chromosome 11p15.3-p15.1, and PTH is intricately linked to parathyroid hormone-related protein (PTH-rP), which, unlike PTH, is produced by various cell types and is involved in regulating endochondral bone development and epithelial-mesenchymal interactions during mammary gland and tooth formation. Both PTH and PTH-rP are influenced by vitamin D and steroid hormones, and these proteins exert their effects by binding to specific PTH/PTH-rP receptors, subsequently activating adenylate cyclase or phospholipase C beta via protein kinase C activation. Anti-PTH antibody (5E745) is an invaluable tool for researchers studying calcium homeostasis and related disorders, providing insights into the physiological and pathological roles of this critical hormone.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTH Antibody (5E745) | sc-71944 | 100 µg/ml | $322.00 |