PP2A-Aα/β Antibody (4G7): sc-13600

PP2A-Aα/β Antibody (4G7) is a mouse monoclonal IgG1 kappa light chain antibody that detects PP2A-A alpha / beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PP2A-Aα/β (4G7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PP2A-A protein plays a crucial role in cellular signaling by acting as a serine/threonine phosphatase, which is essential for regulation of numerous cellular processes such as cell division, apoptosis, and maintaining cellular homeostasis. PP2A-A functions by dephosphorylating target proteins, thereby reversing kinase action and ensuring balanced phosphorylation within cells. This regulatory function controls various signaling pathways, including those involved in cancer progression and other diseases. PP2A family consists of several subunits, including PP2A-Aα and PP2A-Aβ, which can associate with different regulatory subunits to form a trimeric holoenzyme, highlighting complexity and versatility of regulatory mechanisms. Understanding PP2A-A interactions and functions is essential for elucidating roles in health and disease, making PP2A-Aα/β (4G7) antibody a valuable tool for researchers studying these critical biological processes.

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PP2A-Aα/β Antibody (4G7) References:

1. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B).  |  Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
2. PP2A-Mediated Anticancer Therapy.  |  Chen, W., et al. 2013. Gastroenterol Res Pract. 2013: 675429. PMID: 24307892
3. Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes.  |  Zhong, Y., et al. 2019. Nat Commun. 10: 4523. PMID: 31586053
4. Selective PP2A Enhancement through Biased Heterotrimer Stabilization.  |  Leonard, D., et al. 2020. Cell. 181: 688-701.e16. PMID: 32315618
5. The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.  |  Vervoort, SJ., et al. 2021. Cell. 184: 3143-3162.e32. PMID: 34004147
6. Targeting PP2A for cancer therapeutic modulation.  |  Ronk, H., et al. 2022. Cancer Biol Med. 19: 1428-39. PMID: 36342229
7. Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing.  |  Van Eynde, A., et al. 1995. J Biol Chem. 270: 28068-74. PMID: 7499293
8. Serine/threonine protein phosphatases.  |  Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
9. Important roles for novel protein phosphatases dephosphorylating serine and threonine residues.  |  Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
10. A regulatory subunit of smooth muscle myosin bound phosphatase.  |  Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
11. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.  |  Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
12. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth.  |  Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PP2A-Aα/β Antibody (4G7) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-PP2A-Aα/β Antibody (4G7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PP2A-Aα/β Antibody (4G7) Specifications

Alternate Product Name: PP2A phosphatase structural subunit A alpha/beta

Product Clone Name: 4G7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: PP2A-A

Epitope Species: human

Product Reactivity/Detection: PP2A-Aα and PP2A-Aβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for PP2A-Aα/β Antibody (4G7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin