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Mitochondrial polyribonucleotide nucleotidyltransferase, also designated 3'-5' RNA exonuclease, OLD35, PNPase or PNPT1, is an evolutionaly conserved protein in which the mouse protein shares 90% identity with the human version. PNPase (polyribonucleotide nucleotidyltransferase 1) participates in mRNA degradation and hydrolyzes single-stranded ribonucleotides in the 3' to 5' direction. PNPase forms homotrimers and is upregulated in response to interferon-β induction. The N-terminus of PNPase contains a putative mitochondrial targeting sequence; mutation analysis confirms that N-terminal sequences of PNPase target the protein to the mitochondria. Endogenous PNPase also co-localizes with a mitochondrial marker protein in HeLa cells.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PNPase (G-11) | sc-365049 | 200 µg/ml | $316.00 | |||
PNPase (G-11): m-IgG Fc BP-HRP Kit | sc-537765 | 200 µg Ab; 10 µg BP | $354.00 | |||
PNPase (G-11): m-IgGκ BP-HRP Kit | sc-535137 | 200 µg Ab; 40 µg BP | $354.00 | |||
PNPase (G-11): m-IgG1 BP-HRP Kit | sc-545339 | 200 µg Ab; 20 µg BP | $354.00 | |||
PNPase (G-11) peptide neutralisant | sc-365049 P | 100 µg/0.5 ml | $68.00 |