PMP22 Antibody (PMP22H1): sc-65739
- PMP22 Antibody (PMP22H1) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against a 13-mer peptide in the second extracellular domain of PMP22 of human origin
- recommended for detection of residues 121-123 of PMP22 of human and rhesus monkey origin by WB, IP, IF and IHC(P); non cross-reactive with mouse, rat and bovine nerve
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PMP22 Antibody (PMP22H1) for WB and IHC(P) applications. These reagents are now offered in bundles with PMP22 Antibody (PMP22H1) (see ordering information below).
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PMP22 Antibody (PMP22H1) is a mouse monoclonal IgG1 antibody that detects PMP22 in human and rhesus monkey samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PMP22 is a crucial growth-regulated membrane protein predominantly expressed by Schwann cells, where PMP22 plays a vital role in the formation and maintenance of compact myelin in the peripheral nervous system. PMP22 is essential for the proper functioning of peripheral nerves, as PMP22 contributes to the structural integrity and insulation of nerve fibers, facilitating efficient signal transmission. Mutations in the gene encoding PMP22, located on human chromosome 17p11.2, are associated with several neuropathies, including Charcot-Marie-Tooth disease and hereditary neuropathy with liability to pressure palsies, highlighting PMP22′s importance in both health and disease. Anti-PMP22 antibody (PMP22H1) is an invaluable tool for researchers studying myelin-related disorders and the underlying mechanisms of peripheral nerve function.
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PMP22 Antibody (PMP22H1) References:
- Tetraspan myelin protein PMP22 and demyelinating peripheral neuropathies: new facts and hypotheses. | Müller, HW. 2000. Glia. 29: 182-5. PMID: 10625337
- Molecular and clinical features of inherited neuropathies due to PMP22 duplication. | Watila, MM. and Balarabe, SA. 2015. J Neurol Sci. 355: 18-24. PMID: 26076881
- RUNX represses Pmp22 to drive neurofibromagenesis. | Hall, A., et al. 2019. Sci Adv. 5: eaau8389. PMID: 31032403
- Regulating PMP22 expression as a dosage sensitive neuropathy gene. | Pantera, H., et al. 2020. Brain Res. 1726: 146491. PMID: 31586623
- Treating PMP22 gene duplication-related Charcot-Marie-Tooth disease: the past, the present and the future. | Boutary, S., et al. 2021. Transl Res. 227: 100-111. PMID: 32693030
- Candidate imaging biomarkers for PMP22-related inherited neuropathies. | Roth, AR., et al. 2022. Ann Clin Transl Neurol. 9: 925-935. PMID: 35656877
- Downregulation of PMP22 ameliorates myelin defects in iPsc-derived human organoid cultures of CMT1A. | Van Lent, J., et al. 2023. Brain. 146: 2885-2896. PMID: 36511878
- Rare PMP22 variants in mild to severe neuropathy uncorrelated to plasma GDF15 or neurofilament light. | Palu, E., et al. 2023. Neurogenetics. 24: 291-301. PMID: 37606798
- PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells. | Prior, R., et al. 2024. Brain. 147: 3113-3130. PMID: 38743588
- Roles for PMP22 in Schwann cell cholesterol homeostasis in health and disease. | Stefanski, KM., et al. 2024. Biochem Soc Trans. 52: 1747-1756. PMID: 38979632
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMP22 Antibody (PMP22H1) | sc-65739 | 200 µg/ml | $322.00 | |||
PMP22 Antibody (PMP22H1): m-IgG Fc BP-HRP Bundle | sc-537180 | 200 µg Ab; 10 µg BP | $361.00 | |||
PMP22 Antibody (PMP22H1): m-IgGκ BP-HRP Bundle | sc-534381 | 200 µg Ab; 40 µg BP | $361.00 | |||
PMP22 Antibody (PMP22H1): m-IgG1 BP-HRP Bundle | sc-545058 | 200 µg Ab; 20 µg BP | $361.00 |