Molecular structure of PF-3084014, CAS Number: 1290543-63-3
PF-3084014 (CAS 1290543-63-3)
CAS Number:
1290543-63-3
Molecular Weight:
489.6
Molecular Formula:
C27H41F2N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PF-3084014 (CAS 1290543-63-3) References
- γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct. | Ran, Y., et al. 2017. EMBO Mol Med. 9: 950-966. PMID: 28539479
- HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro. | Du, Z., et al. 2018. Int J Oncol. 53: 99-112. PMID: 29658567
- Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells. | Sorrentino, C., et al. 2019. Front Immunol. 10: 162. PMID: 30792717
- Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. | Lessard, CB., et al. 2019. J Biol Chem. 294: 11276-11285. PMID: 31167792
- Identification of FOXN4 as a tumor suppressor of breast carcinogenesis via the activation of TP53 and deactivation of Notch signaling. | Wang, X., et al. 2020. Gene. 722: 144057. PMID: 31430519
- Systematic Evaluation for the Influences of the SOX17/Notch Receptor Family Members on Reversing Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells. | Du, Z., et al. 2021. Front Oncol. 11: 607291. PMID: 33791203
- From Therapy Resistance to Targeted Therapies in Prostate Cancer. | Moreira-Silva, F., et al. 2022. Front Oncol. 12: 877379. PMID: 35686097
- SOX8 Knockdown Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer by Inhibiting the Notch Signaling Pathway. | Du, Z., et al. 2022. Biomed Res Int. 2022: 9235837. PMID: 36246971
- Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer. | Hossain, F., et al. 2023. Front Immunol. 14: 1244159. PMID: 37901240
- Review on anti-alzheimer drug development: approaches, challenges and perspectives. | Abdallah, AE. 2024. RSC Adv. 14: 11057-11088. PMID: 38586442
Inhibitor of:
ADAMTS-L4, Aph-1c, ASCL1, Csl, ENHO, EYA1, GXYLT2, HES4, HES7, ITM2A, Jagged, Jagged1, KIAA1024L_A730017C20Rik, kismet-L, Manic Fringe, Notch, Nrarp, NUMB, PION, Radical Fringe, RAM, RBP-L, SEL-12, TLE5, and X11α.Activator of:
achaete, Aph-1b, Aph-1c, Deltex-3, and Hairless.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PF-3084014, 5 mg | sc-507501 | 5 mg | $130.00 |