PDZK1 Antibody (E-9): sc-390964
- PDZK1 Antibody (E-9) is a mouse monoclonal IgG1 κ PDZK1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 51-97 mapping near the N-terminus of PDZK1 of human origin
- PDZK1 Antibody (E-9) is recommended for detection of PDZK1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PDZK1 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PDZK1 Antibody (E-9) for WB applications. These reagents are now offered in bundles with PDZK1 Antibody (E-9) (see ordering information below).
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PDZK1 Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDZK1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDZK1 (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PDZK1 protein plays a crucial role in cellular signaling and protein scaffolding, particularly in organizing ion channels, which is vital for maintaining cellular homeostasis and communication. PDZK1 is primarily localized to the plasma membrane of epithelial cells, where four PDZ domains interact with multiple types of channels simultaneously, effectively acting as an adaptor between different cell surface receptors. This unique structural feature allows PDZK1 to facilitate complex signaling pathways and maintain cellular function integrity. PDZK1 is significantly upregulated in human carcinomas of epithelial origin, and interactions with proteins such as MAP17 and cMOAT suggest a potential role in multidrug resistance, making PDZK1 a promising target for therapeutic strategies aimed at overcoming resistance in cancer cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PDZK1 Antibody (E-9) References:
- Targeted disruption of the PDZK1 gene by homologous recombination. | Kocher, O., et al. 2003. Mol Cell Biol. 23: 1175-80. PMID: 12556478
- Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI. | Kocher, O. and Krieger, M. 2009. Curr Opin Lipidol. 20: 236-41. PMID: 19421056
- SR-B1 and PDZK1: partners in HDL regulation. | Trigatti, BL. 2017. Curr Opin Lipidol. 28: 201-208. PMID: 28134663
- PDZK1 induces resistance to apoptosis in esophageal adenocarcinoma cells. | Handa, O., et al. 2021. Esophagus. 18: 655-662. PMID: 33586076
- Roles of circ_0000135/miR-140-3p/PDZK1 network in cervical cancer. | Wang, N., et al. 2022. Clin Transl Oncol. 24: 1086-1099. PMID: 35066758
- Downregulation of PDZK1 by TGF-β1 promotes renal fibrosis via inducing epithelial-mesenchymal transition of renal tubular cells. | Lu, S., et al. 2024. Biochem Pharmacol. 220: 116015. PMID: 38158021
- miR-101-3p-mediated role of PDZK1 in hepatocellular carcinoma progression and the underlying PI3K/Akt signaling mechanism. | Gao, H., et al. 2024. Cell Div. 19: 9. PMID: 38532426
- PDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway. | Ma, Y., et al. 2024. Cell Death Dis. 15: 199. PMID: 38604999
- The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies. | Leask, MP., et al. 2024. Nat Rev Rheumatol. 20: 510-523. PMID: 38992217
- PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function. | Shao, Y., et al. 2024. Bone Res. 12: 41. PMID: 39019845
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDZK1 Antibody (E-9) | sc-390964 | 200 µg/ml | $322.00 | |||
PDZK1 Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-530317 | 200 µg Ab; 10 µg BP | $361.00 | |||
PDZK1 Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-523754 | 200 µg Ab, 40 µg BP | $361.00 | |||
PDZK1 Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-543988 | 200 µg Ab; 20 µg BP | $361.00 | |||
PDZK1 Antibody (E-9) AC | sc-390964 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PDZK1 Antibody (E-9) HRP | sc-390964 HRP | 200 µg/ml | $322.00 | |||
PDZK1 Antibody (E-9) FITC | sc-390964 FITC | 200 µg/ml | $336.00 | |||
PDZK1 Antibody (E-9) PE | sc-390964 PE | 200 µg/ml | $349.00 | |||
PDZK1 Antibody (E-9) Alexa Fluor® 488 | sc-390964 AF488 | 200 µg/ml | $364.00 | |||
PDZK1 Antibody (E-9) Alexa Fluor® 546 | sc-390964 AF546 | 200 µg/ml | $364.00 | |||
PDZK1 Antibody (E-9) Alexa Fluor® 594 | sc-390964 AF594 | 200 µg/ml | $364.00 | |||
PDZK1 Antibody (E-9) Alexa Fluor® 647 | sc-390964 AF647 | 200 µg/ml | $364.00 | |||
PDZK1 Antibody (E-9) Alexa Fluor® 680 | sc-390964 AF680 | 200 µg/ml | $364.00 | |||
PDZK1 Antibody (E-9) Alexa Fluor® 790 | sc-390964 AF790 | 200 µg/ml | $364.00 |