Anticorps PDZK1 (42): sc-136028
- L'anticorps PDZK1 42 est un monoclonal IgG1 de souris fourni en 50 µg/0.5 ml
- dirigé contre les acides aminés 431-523 de PDZK1 d'origine rat
- recommandé pour la détection de PDZK1 d'origine mouse et rat par WB et IP
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire PDZK1 (42). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
ACCÈS RAPIDE AUX LIENS
Proteins containing PDZ domains play a role in a wide array of biological functions including protein scaffolding, organization of ion channels, and signal transduction. The PDZ domain containing protein PDZK1 interacts with multiple targets, including MAP17 and cMOAT and also NaPi-IIa, which implicates PDZK1 in ion channel formation. PDZK1 localizes to the plasma membrane of epithelial cells, where it is able to interact simultaneously with more than one type of channel, by utilizing its 4 PDZ domains, and thus acts as an adaptor between different cell surface receptors. Furthermore, PDZK1 is markedly upregulated in human carcinomas of epithelial origin, and the cluster formed by its association with cMOAT and MAP17 may potentially play role in multidrug resistance. Therefore, PDZK1 may be a new target for cancers cells resistance to chemotherapeutic agents.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PDZK1 (42) | sc-136028 | 50 µg/0.5 ml | $316.00 |