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Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDIR (Protein disulfide isomerase-related protein), also known as PDIA5 (Protein disulfide-isomerase A5), is a 519 amino acid protein that catalyzes the rearrangement of sulfur-sulfur bonds in various proteins. Localized to the lumen of the endoplasmic reticulum (ER), PDIR has an oxidative refolding activity that is specific for α1-antitrypsin (AAT) and aids in the formation of disulfide bonds in the ER lumen. PDIR contains one ER retention signal at its C-terminus and three thioredoxin (CXXC) motifs which mediate the substrate-specific isomerase, chaperone and redox activity of PDIR.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PDIR (H-8) | sc-376164 | 200 µg/ml | $316.00 | |||
PDIR (H-8): m-IgG Fc BP-HRP Kit | sc-540523 | 200 µg Ab; 10 µg BP | $354.00 | |||
PDIR (H-8): m-IgG1 BP-HRP Kit | sc-542180 | 200 µg Ab; 20 µg BP | $354.00 |