OATP-A Antibody (E-7): sc-365007
- OATP-A Antibody (E-7) is a mouse monoclonal IgG2b κ OATP-A antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 611-665 mapping near the C-terminus of OATP-A of human origin
- OATP-A Antibody (E-7) is recommended for detection of OATP-A of human origin by WB, IP, IF and ELISA
- Anti-OATP-A Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for OATP-A Antibody (E-7) for WB applications. This reagent is now offered in a bundle with OATP-A Antibody (E-7) (see ordering information below).
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OATP-A Antibody (E-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects OATP-A of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OATP-A (E-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The organic anion transporting polypeptide OATP-A, also known as OATP1, OATP1A2, and SLC21A3, plays a crucial role in the hepatic uptake of various anionic steroid conjugates, such as dehydroepiandrosterone sulfate and estradiol-17-glucuronide, which are essential for maintaining hormonal balance and metabolic processes. OATP-A is primarily expressed in the liver and kidney, facilitating sodium-independent transport of these compounds, which is vital for their biological activity and elimination from the body. Notably, OATP-A′s interaction with other proteins, such as OATP-C, highlights its importance in the transport of cardiac glycosides and other substrates, underscoring its role in drug metabolism and pharmacokinetics. The expression of OATP-C is inducible by certain compounds, which can affect the liver′s capacity to extract cardiac glycosides from plasma, further illustrating the functional interplay between these transport proteins. Anti-OATP-A antibody (E-7) is therefore an invaluable tool for researchers studying the dynamics of organic anion transport and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OATP-A Antibody (E-7) References:
- A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. | Hsiang, B., et al. 1999. J Biol Chem. 274: 37161-8. PMID: 10601278
- Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. | König, J., et al. 2000. J Biol Chem. 275: 23161-8. PMID: 10779507
- Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin. | Cao, J., et al. 2001. Hepatology. 33: 140-7. PMID: 11124830
- Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney. | Isern, J., et al. 2001. Biochim Biophys Acta. 1518: 73-8. PMID: 11267661
- Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. | Rausch-Derra, LC., et al. 2001. Hepatology. 33: 1469-78. PMID: 11391536
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OATP-A Antibody (E-7) | sc-365007 | 200 µg/ml | $322.00 | |||
OATP-A Antibody (E-7): m-IgG2b BP-HRP Bundle | sc-548714 | 200 µg Ab; 10 µg BP | $361.00 | |||
OATP-A Antibody (E-7) AC | sc-365007 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OATP-A Antibody (E-7) HRP | sc-365007 HRP | 200 µg/ml | $322.00 | |||
OATP-A Antibody (E-7) FITC | sc-365007 FITC | 200 µg/ml | $336.00 | |||
OATP-A Antibody (E-7) PE | sc-365007 PE | 200 µg/ml | $349.00 | |||
OATP-A Antibody (E-7) Alexa Fluor® 488 | sc-365007 AF488 | 200 µg/ml | $364.00 | |||
OATP-A Antibody (E-7) Alexa Fluor® 546 | sc-365007 AF546 | 200 µg/ml | $364.00 | |||
OATP-A Antibody (E-7) Alexa Fluor® 594 | sc-365007 AF594 | 200 µg/ml | $364.00 | |||
OATP-A Antibody (E-7) Alexa Fluor® 647 | sc-365007 AF647 | 200 µg/ml | $364.00 | |||
OATP-A Antibody (E-7) Alexa Fluor® 680 | sc-365007 AF680 | 200 µg/ml | $364.00 | |||
OATP-A Antibody (E-7) Alexa Fluor® 790 | sc-365007 AF790 | 200 µg/ml | $364.00 |