ACCÈS RAPIDE AUX LIENS
Nucleobindin, also designated Nuc or Calnuc, is a secreted protein that promotes production of DNA-specific antibodies in lupus-prone MRL/lpr mice. Nucleobindin contains a signal peptide, two EF-hand motifs, acidic and basic regions and a leucine-zipper motif. Nucleobindin has two calcium-binding domains and is the major Golgi Ca2+ binding protein. The leucine zipper structure and the basic amino acid-rich region are responsible for DNA binding. Nucleobindin preferentially associates with membranes of polarized cells. Nucleobindin is found in both the cytosol and the membrane and is localized to cis-Golgi cisternae and the cis-Golgi network (CGN). Nucleobindin is involved in autoimmunity, apoptosis and calcium homeostasis in the bone matrix.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps nucleobindin (R-Y2) | sc-100793 | 100 µg/ml | $333.00 |