Anticorps Nix (E-1): sc-166314
- L'Anticorps Nix (E-1) est un monoclonal de souris IgG1 κ, cité dans 2 publications, fourni en 200 µg/ml
- spécifique d'un épitope situé entre les acides aminés 19-47 près de N-terminus de Nix d'origine human
- recommandé pour la détection de Nix d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire Nix (E-1). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include Nip1, Nip2, Nip3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. Nip1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. Nip2 shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, Nip2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to Nip3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins. Nip3 preferentially binds to Bcl-xL and induces apoptosis by suppressing the anti-apoptosis activity of Bcl-xL.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Nix (E-1) | sc-166314 | 200 µg/ml | $316.00 | |||
Nix (E-1) peptide neutralisant | sc-166314 P | 100 µg/0.5 ml | $68.00 |