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NCDN (neurochondrin) is a 729 amino acid leucine-rich cytoplasmic protein belonging to the neurochondrin family that is involved in nervous system signal transduction and required for spatial learning. Known to act as a negative regulator of CaMKII (Ca2+-calmodulin-dependent protein kinase 2) phosphorylation, NCDN may also associate with MCH-1R (melanin-concentrating hormone receptor 1) to modulate its function, and is suggested to play a role in bone metabolism, neurite outgrowth and chondrocyte differentiation. Due to alternative splicing events, three NCDN isoforms are known to exist which are highly expressed in adult brain and spinal cord, and found at lower levels in fetal brain, ovary and testis. Localizing to somatic regions of neurons, NCDN is encoded by a gene that maps to human chromosome 1p34.3 and mouse chromosome 4 D2.2.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps NCDN (F-12) | sc-398588 | 200 µg/ml | $316.00 | |||
NCDN (F-12) peptide neutralisant | sc-398588 P | 100 µg/0.5 ml | $68.00 |