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Sialic acids are a family of 9-carbon 2-keto-3-deoxy sugars that are found on the ends of glycoproteins and glycolipids and play important roles in recognition events within the cell. NANS (N-acetylneuraminic acid synthase), also known as SAS, is a 359 amino acid protein that contains one AFP (antifreeze protein)-like domain and functions in the biosynthesis of sialic acids. Expressed ubiquitously, NANS enzymatically catalyzes the H2O-dependent formation of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), both of which are sialic acids. NANS uses N-acetylmannosamine 6-phosphate as a substrate for Neu5Ac synthesis and mannose 6-phosphate as a substrate for KDN synthesis. Human NANS shares 36% identity with the E. coli protein neuB, suggesting a conserved function between species.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps NANS (B-1) | sc-514091 | 200 µg/ml | $316.00 | |||
NANS (B-1) peptide neutralisant | sc-514091 P | 100 µg/0.5 ml | $68.00 |