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alpha 3 Sodium Potassium ATPase/ATP1A3 抗体 (G-6): sc-376967

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  • alpha 3 Sodium Potassium ATPase/ATP1A3抗体(G-6)是小鼠单克隆IgG1 κ, 在2篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列1-65位于human物种的Na+/K+-ATPase α3的N-terminus
  • 推荐用于 mouse, rat 和 human 来源的Na+/K+-ATPase α3 WB, IP, IF 和 ELISA检测
  • 看 ATP1A1/ATP1A2/ATP1A3/ATP1A4 (M7-PB-E9): sc-58628,可查看有标记的 alpha 3 Sodium Potassium ATPase/ATP1A3 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是alpha 3 Sodium Potassium ATPase/ATP1A3 Antibody (G-6) for WB applications. 的首选辅助检测试剂,这些试剂现与alpha 3 Sodium Potassium ATPase/ATP1A3 Antibody (G-6) 打包提供(请参阅下面的订购信息)。
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関連項目

普遍表达的钠/钾ATP酶(Na+/K+-ATP酶)以寡聚体细胞膜复合物的形式存在,它可以将一个ATP分子的水解与逆着各自电化学梯度转运三个Na+离子和两个K+离子相偶联。作为P型离子动力家族的一员,Na+/K+-ATP酶在维持细胞体积、静息膜电位和Na+偶联溶质转运方面发挥着关键作用。Na+/K+-ATP酶的寡聚体由α、β和γ三个亚基的多种异构体组成。α亚基包含ATP和阳离子的结合位点;糖基化的β亚基确保α亚基的正确折叠和膜插入。小γ亚基在肾单位段中与α亚基共定位,从而提高Na+/K+-ATP酶对ATP的亲和力。对于Na+/K+-ATP酶的正常活性而言,β亚基是必不可少的,而γ亚基则非必需。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

alpha 3 Sodium Potassium ATPase/ATP1A3 抗体 (G-6) 参考文献:

  1. 17β-雌二醇优先降低Na+/K+ ATPase α3,影响大鼠子宫的收缩频率。  |  Tsai, ML., et al. 2000. Chin J Physiol. 43: 1-8. PMID: 10857462
  2. Na-K-ATPase α3基因启动子中甲状腺调节因子的鉴定。  |  Bajpai, M., et al. 2001. Mol Biol Rep. 28: 1-7. PMID: 11710559
  3. Na+/K+ -ATPase alpha3基因ATP1A3的突变与快速发作性肌张力障碍帕金森症有关。  |  de Carvalho Aguiar, P., et al. 2004. Neuron. 43: 169-75. PMID: 15260953
  4. Reevesioside F通过Na⁺/K⁺-ATPase α3亚基参与的线粒体应激和caspase cascades扩增诱导强效的抗增殖和细胞凋亡活性。  |  Chan, SH., et al. 2013. Biochem Pharmacol. 86: 1564-75. PMID: 24099795
  5. 通过双相情感障碍的前瞻性疗法(褪黑素和运动)减轻Na(+),K(+)-ATPase α3突变小鼠的躁狂行为。  |  Kirshenbaum, GS., et al. 2014. Neuroscience. 260: 195-204. PMID: 24342563
  6. 阿尔茨海默氏症毒性淀粉样β寡聚体:Na/K ATP酶α3对接站的"不速之客"。  |  DiChiara, T., et al. 2017. Yale J Biol Med. 90: 45-61. PMID: 28356893
  7. 精神疾病中额叶皮质GABA能神经元中的Na+、K+-ATP酶α3同工型  |  Hodes, A., et al. 2019. J Psychiatr Res. 115: 21-28. PMID: 31082653
  8. 强心苷通过细胞内 Na+ 、K+-ATPase α3-异构体刺激人类癌细胞中 GLUT1 的内吞。  |  Fujii, T., et al. 2022. J Cell Physiol. 237: 2980-2991. PMID: 35511727
  9. Na,K-ATPase alpha3亚基基因的启动子由顺式元件组成,NF-Y和Sp1/Sp3在大鼠心肌细胞中结合到这些元件上。  |  Murakami, Y., et al. 1997. Biochim Biophys Acta. 1352: 311-24. PMID: 9224955
  10. 视黄酸选择性诱导心脏肌细胞中Na,K-ATP酶α3亚基mRNA丰度。  |  Chin, S., et al. 1998. J Mol Cell Cardiol. 30: 2403-10. PMID: 9925375

订购信息

产品名称产品编号规格价格数量收藏夹

alpha 3 Sodium Potassium ATPase/ATP1A3 抗体 (G-6)

sc-376967
200 µg/ml
$322.00

alpha 3 Sodium Potassium ATPase/ATP1A3 (G-6): m-IgG Fc BP-HRP 套装

sc-540676
200 µg Ab; 10 µg BP
$361.00

alpha 3 Sodium Potassium ATPase/ATP1A3 (G-6): m-IgG1 BP-HRP 套装

sc-542291
200 µg Ab; 20 µg BP
$361.00

Can I use conventional mouse secondary antibody for this product?

Asked by: shororo
Thank you for your question. Na+/K+-ATPase α3 Antibody (G-6) is a mouse monoclonal IgG1 (kappa light chain). Yes, you can use any conventional anti-mouse IgG secondary antibody for detection with this primary antibody.
Answered by: Technical Support
Date published: 2019-01-26

I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-376967: Na+/K+-ATPase α3 (G-6) mouse monoclonal antibody will work?

Asked by: Trav11
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by SS from Produced positive Western blot data of Na+/K+Produced positive Western blot data of Na+/K+-ATPase 3 expression in THP-1 whole cell lysate. -SCBT QC
Date published: 2013-12-02
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alpha 3 Sodium Potassium ATPase/ATP1A3 抗体 (G-6) is rated 5.0 out of 5 by 1.
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