In mammalian cells, transcription is regulated in part by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex is one such multi-protein structure that functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription. Med8 (mediator complex subunit 8), also known as arc32 (activator-recruited cofactor 32 kDa component), is a 268 amino acid protein that localizes to the nucleus and exists as a component of the mediator complex. Involved in the pathway of protein modification and ubiquitination, Med8 is involved in transcriptional regulation and may also recruit E3 ubiquitin-protein ligase complexes to proteins targeted for proteasomal degradation. Multiple isoforms of Med8 exist due to alternative splicing events.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Med8 (A-3) | sc-365713 | 200 µg/ml | $316.00 | |||
Med8 (A-3): m-IgGκ BP-HRP Kit | sc-535243 | 200 µg Ab; 40 µg BP | $354.00 |