LMP2 Antibody (A-1): sc-271354

LMP2 Antibody (A-1) is a mouse monoclonal IgG2a antibody that detects LMP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LMP2 is a crucial component of the proteasome, a multicatalytic proteinase complex that plays a vital role in the regulated degradation of ubiquitinated proteins, thereby maintaining cellular homeostasis and regulating various cellular processes, including the cell cycle and apoptosis. The proteasome is located in both the nucleus and cytoplasm, where LMP2 comprises at least 15 nonidentical subunits arranged in a highly ordered ring structure. LMP2, along with LMP7, is particularly significant as these low molecular mass proteins are involved in the MHC class I antigen-processing pathway, which is essential for the activation of cytotoxic T cells in response to viral infections and tumor cells. Upon stimulation with interferon-gamma, LMP2 and LMP7 replace housekeeping subunits in the proteasome, enhancing the proteolytic activity necessary for generating peptides that are presented on MHC class I molecules. LMP2 is expressed in two alternatively spliced forms, LMP2.l and LMP2.s, which are produced in lymphoblastoid cell lines and fibroblasts following interferon-gamma stimulation, highlighting this protein′s dynamic regulation in immune responses. Anti-LMP2 antibody (A-1) is an invaluable tool for researchers studying the proteasome′s role in cellular regulation and immune function.

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LMP2 Antibody (A-1) References:

1. LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians.  |  Vargas-Alarcón, G., et al. 2002. Genes Immun. 3: 373-7. PMID: 12209365
2. The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).  |  Dawson, CW., et al. 2012. Semin Cancer Biol. 22: 144-53. PMID: 22249143
3. LMP2, a novel immunohistochemical marker to distinguish renal oncocytoma from the eosinophilic variant of chromophobe renal cell carcinoma.  |  Zheng, G., et al. 2013. Exp Mol Pathol. 94: 29-32. PMID: 22705098
4. Latent Membrane Protein 2 (LMP2).  |  Cen, O. and Longnecker, R. 2015. Curr Top Microbiol Immunol. 391: 151-80. PMID: 26428374
5. Constructing TC-1-GLUC-LMP2 Model Tumor Cells to Evaluate the Anti-Tumor Effects of LMP2-Related Vaccines.  |  Sun, L., et al. 2018. Viruses. 10: PMID: 29570629
6. LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins.  |  Zanker, D., et al. 2018. Immunol Cell Biol. 96: 981-993. PMID: 29738610
7. Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia.  |  Du, SH., et al. 2020. Front Immunol. 11: 603278. PMID: 33552061
8. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis.  |  Li, J., et al. 2023. Cardiovasc Res. 119: 1030-1045. PMID: 36464772
9. A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma.  |  Guo, M., et al. 2023. Nano Res. 16: 5357-5367. PMID: 36618068
10. LMP2 and TAP2 impair tumor growth and metastasis by inhibiting Wnt/β-catenin signaling pathway and EMT in cervical cancer.  |  Cheng, Z., et al. 2023. BMC Cancer. 23: 1128. PMID: 37986152

The preferred LMP2 antibody is LMP2 Antibody (G-2): sc-373971.