ACCÈS RAPIDE AUX LIENS
LCOR (Ligand-dependent corepressor), also referred as MLR2, is a 433 amino acid transcriptional corepressor that contains an LXXLL motif, a nuclear localization signal and a helix-loop-helix domain. LCOR is widely expressed in fetal and adult tissues and is recruited to nuclear receptors through its LXXLL motif. LCOR interacts with several estrogen receptors, such as ERα and ERβ in the presence of estradiol. Additionally, LCOR acts as a molecular scaffold, functioning to recruit proteins involved in transcriptional repression to the DNA. LCOR activity is inhibited in a receptor-dependent fashion by the HDAC (histone deacetylase) inhibitor trichostatin A, suggesting HDAC-dependent mode of action. LCOR functions in a negative feedback loop to reduce hormone-induced transactivation.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps LCOR (C-4) | sc-398636 | 200 µg/ml | $316.00 | |||
LCOR (C-4) peptide neutralisant | sc-398636 P | 100 µg/0.5 ml | $68.00 |