JNJ-61393215 (CAS 1637681-55-0)
Alternate Names:
JNJ61393215
CAS Number:
1637681-55-0
Molecular Weight:
460.43
Molecular Formula:
C23H16D2F4N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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JNJ-61393215 (CAS 1637681-55-0) References
- Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis. | Rappas, M., et al. 2020. J Med Chem. 63: 1528-1543. PMID: 31860301
- Structure-based development of a subtype-selective orexin 1 receptor antagonist. | Hellmann, J., et al. 2020. Proc Natl Acad Sci U S A. 117: 18059-18067. PMID: 32669442
- Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans. | Salvadore, G., et al. 2020. Transl Psychiatry. 10: 308. PMID: 32895369
- The Insomnia-Addiction Positive Feedback Loop: Role of the Orexin System. | Fragale, JE., et al. 2021. Front Neurol Neurosci. 45: 117-127. PMID: 34052815
- Identification of Highly Selective Orexin 1 Receptor Antagonists Driven by Structure-Based Design. | Lessel, U., et al. 2021. J Chem Inf Model. 61: 5893-5905. PMID: 34817173
- Hypocretins (orexins): The ultimate translational neuropeptides. | Jacobson, LH., et al. 2022. J Intern Med. 291: 533-556. PMID: 35043499
- CO2 reactivity as a biomarker of exposure-based therapy non-response: study protocol. | Smits, JAJ., et al. 2022. BMC Psychiatry. 22: 831. PMID: 36575425
- Discovery and first-time disclosure of CVN766, an exquisitely selective orexin 1 receptor antagonist. | Glen, A., et al. 2024. Bioorg Med Chem Lett. 100: 129629. PMID: 38295907
- Evaluating the efficacy of the selective orexin 1 receptor antagonist nivasorexant in an animal model of binge-eating disorder. | Steiner, MA., et al. 2024. Int J Eat Disord.. PMID: 38456603
- Machine learning models to predict ligand binding affinity for the orexin 1 receptor. | Zhang, VY., et al. 2024. Artif Intell Chem. 2: PMID: 38476266
Inhibitor of:
Orexin R-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNJ-61393215, 50 mg | sc-507326 | 50 mg | $1800.00 |