Anti-L'anticorps IGFBP1 H-5 est un monoclonal IgG1 κ L'Anticorps IGFBP1, cité dans 7 publications, fourni en 200 µg/ml
dirigé contre les acides aminés 121-240 de IGFBP1 d'origine human
Anti-L'Anticorps IGFBP1 (H-5) est recommandé pour la détection de IGFBP1 d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
Anti-L'Anticorps IGFBP1 (H-5) est disponible conjugué à l'agarose pour IP; à l'HRP pour WB, IHC(P) et ELISA; et soit à la phycoerythrin ou FITC pour IF, IHC(P) et FCM
aussi disponible conjugué à l'Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 ou Alexa Fluor® 647 pour WB (RGB), IF, IHC(P) et FCM
aussi disponible conjugué à l'Alexa Fluor® 680 ou Alexa Fluor® 790 pour WB (NIR), IF et FCM
Contactez notre Service Technique (ou votre Distributeur local) pour plus d'informations pour recevoir un échantillon GRATUIT de 10 µg de IGFBP1 (H-5): sc-55474.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for IGFBP1 Antibody (H-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with IGFBP1 Antibody (H-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Les Produits Chimiques ChemCruz™
IGFBP Inhibiteurs pour l'analyse fonctionnelle des réponses cellulaires de IGFBP
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IGFBP1 Antibody (H-5) is a high quality monoclonal IGFBP1 antibody (also designated IBP1 antibody) suitable for the detection of the IGFBP1 protein of mouse, rat and human origin. IGFBP1 Antibody (H-5) is available as both the non-conjugated anti-IGFBP1 antibody form, as well as multiple conjugated forms of anti-IGFBP1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Insulin-like growth factor-binding proteins (IGFBPs), a family of homologous proteins that have co-evolved with the IGFs, serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, and their concentration and distribution in the extracellular environment. The IGFBPs also appear to have biological activity independent of the IGFs. Seven IGFBPs have been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP1 is negatively regulated by Insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. IGFBP2, which may function as a chaperone, escorting IGFs to their target tissues, is expressed in several human tissues including fetal eye and fetal brain. IGFBP3, the most abundant IGFBP, is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury. IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation. IGFBP6 differs from other IGFBPs in having the highest affinity for IGF-II. Glycosylated human IGFBP6 is expressed in Chinese hamster ovary (CHO) cells, whereas non-glycosylated recombinant human IGFBP-6 is expressed in E.coli. IGFBP7, a secreted protein that binds both IGF-I and IGF-II with a relatively low affinity, stimulates prostacyclin production and may also function as a growth-suppressing factor.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Can IGFBP1 (H-5): sc-55474 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Posée par: jerojero
Thank you for your question. Yes, IGFBP1 (H-5): sc-55474 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Répondue par: Technical Support
Date de publication: 2018-04-02
For the example immunoperoxidase staining with IGFBP1 Antibody (H-5): sc-55474 antibody? At what concentration did you use for human placenta tissue?
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