ACCÈS RAPIDE AUX LIENS
Indoleamine 2,3-dioxygenase (IDO) is an IFN-γ inducible enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. The gene encoding human IDO maps to chromosome 8p12-p11. IDO, also known as INDO, is an important modulator of immunological responses and protects allogeneic concepti from alloreactive maternal lymphocytes. IDO mediates an interesting inhibitory effect of HeLa cells co-cultured with human PBLs. The ILN-2-induced proliferation response of PBLs is diminished in the presence of HeLa cells while an IDO inhbitor negates this effect. Flow cytometric analysis indicates both mature and immature CD123-positive dentritic cells suppress T cell activity using IDO. IDO-transfected cells co-cultured with T cells reduces T cell proliferation. Additionally, adopted transfer of donor T cells reduces donor T cell numbers in IDO-transgenic mice. The pharmacological or genetic manipulation of IDO may be useful for supressing undesirable T cell response.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps IDO (E-7) | sc-365086 | 200 µg/ml | $316.00 | |||
IDO (E-7): m-IgG Fc BP-HRP Kit | sc-540307 | 200 µg Ab; 10 µg BP | $354.00 | |||
IDO (E-7): m-IgG1 BP-HRP Kit | sc-542029 | 200 µg Ab; 20 µg BP | $354.00 | |||
IDO (E-7) peptide neutralisant | sc-365086 P | 100 µg/0.5 ml | $68.00 |