HuR/ELAV1 Antibody (G-5): sc-374285
- HuR/ELAV1 Antibody (G-5) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-280 of HuR of human origin
- recommended for detection of HuR, HuB, HuC and HuD of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See HuR/ELAV1 (3A2): sc-5261 for HuR/ELAV1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP is the preferred secondary detection reagent for HuR/ELAV1 Antibody (G-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with HuR/ELAV1 Antibody (G-5) (see ordering information below).
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HuR Antibody (G-5) is a mouse monoclonal IgG2a antibody that detects HuR in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). HuR, also known as HuA, is a member of the Elav-like family of RNA-binding proteins and plays a crucial role in post-transcriptional regulation of gene expression. HuR is predominantly located in the nucleus, where HuR binds to AU-rich elements in the 3′-untranslated region of mRNA transcripts, thereby stabilizing them and preventing their rapid degradation. HuR′s ability to shuttle between the nucleus and cytoplasm is vital, as this movement allows for dynamic regulation of mRNA stability and translation, which is essential for cellular responses to stress and differentiation. Notably, HuR is overexpressed in various tumors, highlighting HuR′s importance in cancer biology and making HuR a significant target for therapeutic interventions. Anti-HuR antibody (G-5) provides a reliable tool for researchers aiming to study the expression and function of this critical protein in different biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HuR/ELAV1 Antibody (G-5) References:
- Functional interplay between RNA-binding protein HuR and microRNAs. | Srikantan, S., et al. 2012. Curr Protein Pept Sci. 13: 372-9. PMID: 22708488
- Dysregulation of TTP and HuR plays an important role in cancers. | Wang, H., et al. 2016. Tumour Biol. 37: 14451-14461. PMID: 27644249
- Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells. | Zhang, Z., et al. 2018. Autophagy. 14: 2083-2103. PMID: 30081711
- HuR Promotes Ovarian Cancer Cell Proliferation by Regulating TIMM44 mRNA Stability. | Yu, X., et al. 2020. Cell Biochem Biophys. 78: 447-453. PMID: 32901414
- ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy. | Chen, HY., et al. 2021. Mol Med. 27: 14. PMID: 33568052
- Mechanisms of HuR in regulation of epithelial cell apoptosis in rat ulcerative colitis. | Guo, H., et al. 2021. Cell Signal. 82: 109957. PMID: 33607255
- Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis. | Liu, S., et al. 2021. Cell Death Dis. 12: 385. PMID: 33837179
- HuR Affects the Radiosensitivity of Esophageal Cancer by Regulating the EMT-Related Protein Snail. | Hu, Y., et al. 2022. Front Oncol. 12: 883444. PMID: 35664798
- Down-regulation of HuR inhibits pathological angiogenesis in oxygen-induced retinopathy. | Huang, XM., et al. 2023. Exp Eye Res. 227: 109378. PMID: 36603796
- Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis. | Yadav, V., et al. 2024. Cancers (Basel). 16: PMID: 39335155
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HuR/ELAV1 Antibody (G-5) | sc-374285 | 200 µg/ml | $322.00 | |||
HuR/ELAV1 Antibody (G-5): m-IgG2a BP-HRP Bundle | sc-546054 | 200 µg Ab; 10 µg BP | $361.00 |