Anticorps HIV-1 RT (AS34): sc-52767

Reverse Transcriptase (RT) is a DNA polymerase that will either use an RNA or DNA strand as a primer. Retroviruses use the enzyme RT to transcribe their single-stranded RNA genome into single-stranded DNA and to then construct a complementary strand of DNA. As a result, RT provides a DNA double helix capable of integration into host cell chromosomes. The host cell lysine tRNA, which partially unfolds and anneals to the 5' end of the viral genomic RNA, primes the double stranded DNA production. HIV-1 uses RT to infect humans and HIV-1 RT is a heterodimer. RT inhibitors were the first anti-HIV medications and are divided into two classes based on their structure and action: nucleoside analogues and non-nucleoside reverse transcriptase inhibitors. AZT is one such drug which causes chain termination of the polymerase reaction.

L'anticorps HIV-1 RT préféré est l'Anticorps HIV-1 RT (39/4.12.2): sc-57829.