ACCÈS RAPIDE AUX LIENS
The herpes simplex virus (HSV) infection is initiated by VP16, a viral transcription factor that activates the viral immediate-early (IE) genes. VP16 recognizes the IE gene promoters by forming a multiprotein complex with Oct-1 and HCF1 (host cell factor 1), a nuclear protein required for progression through the G1 phase of the cell cycle. This multiprotein complex, called C1, is responsible for transcription of the HSV immediate-early genes and may be critical for the regulation of the HSV lytic-latent cycle. A second HCF-like protein, designated HCF2 is smaller than HCF1 and is homologous with HCF1 in the beta-propeller domain, which is required for association with VP16. HCF2 associates with VP16 and supports complex assembly with Oct-1 and DNA, although binds VP16 less efficiently than HCF1. This VP16 binding selectivity is dictated by differences in the kelch repeats of the beta-propeller domains of HCF1 and HCF2.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps HCF2 (D-12) | sc-393251 | 200 µg/ml | $316.00 | |||
HCF2 (D-12): m-IgGκ BP-HRP Kit | sc-535735 | 200 µg Ab; 40 µg BP | $354.00 | |||
HCF2 (D-12): m-IgG2b BP-HRP Kit | sc-549474 | 200 µg Ab; 10 µg BP | $354.00 |