HAP1 Antibody (A-11): sc-398581

HAP1 Antibody (A-11) is a mouse monoclonal IgG2a antibody that detects HAP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HAP1, or huntingtin-associated protein 1, plays a crucial role in neuronal cellular dynamics by binding to huntingtin, a protein that, when containing an expanded polyglutamine repeat region exceeding 35 residues, is implicated in Huntington′s disease pathogenesis. The interaction between HAP1 and huntingtin is particularly significant as enhanced by the presence of this expanded region, which may influence huntingtin aggregation and toxicity in affected neurons. HAP1 is predominantly expressed in brain tissue, with notable localization in the olfactory bulb and brain stem, highlighting HAP1′s importance in neuronal function and signaling. Additionally, HAP1 associates with various intracellular organelles, including large endosomes and budding vesicles, which are essential for intracellular transport and communication within neurons. HAP1′s ability to co-localize with huntingtin in nerve fibers underscores HAP1′s potential role in neurodegenerative disease pathology, making anti-HAP1 antibody (A-11) a valuable tool for researchers studying these critical interactions and their implications in human health.

The preferred HAP1 antibody is HAP1 Antibody (C-3): sc-166245.