Anticorps gp91phox/CYBB/NOX2 (NL7): sc-130548
- L'Anticorps gp91phox/CYBB/NOX2 (NL7) est un monoclonal de souris IgG1 κ, cité dans 9 publications, fourni en 200 µg/ml
- élevé contre gp91-phox partiellement purifié d'origine human, avec cartographie de l'épitope sur les acides aminés 498-507
- recommandé pour la détection de gp91-phox d'origine mouse, rat et human par WB, IP, IF, IHC(P) et FCM
- disponible conjugué soit à la phycoérythrine soit à la FITC pour IF, IHC(P) et FCM
- Voir gp91phox/CYBB/NOX2 (54.1): sc-130543 pour d'autres anticorps conjugués gp91phox/CYBB/NOX2, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- m-IgG Fc BP-HRP et m-IgG1 BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps gp91phox/CYBB/NOX2 (NL7) pour des applications de WB and IHC(P). Ces réactifs sont maintenant proposés en kit avec l'anticorps gp91phox/CYBB/NOX2 (NL7) (voir Informations pour la commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane, where they associate with the flavocytochrome cytochrome b558 to form the active enzyme complex. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet they have distinct expression patterns. gp91-phox is expressed in eosinophils, neutrophils, monocytes and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, and low expression is also detected in the uterus and prostate. Mox1 is also upregulated in vascular smooth-muscle cells in response to PDGF stimulation, which collectively indicates that Mox1 may function analogously to gp91-phox, yet regulate the NADPH superoxide production in non-phagocytic cells.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps gp91phox/CYBB/NOX2 (NL7) | sc-130548 | 200 µg/ml | $316.00 | |||
gp91phox/CYBB/NOX2 (NL7): m-IgG Fc BP-HRP Kit | sc-539826 | 200 µg Ab; 10 µg BP | $354.00 | |||
gp91phox/CYBB/NOX2 (NL7): m-IgG1 BP-HRP Kit | sc-541733 | 200 µg Ab; 20 µg BP | $354.00 | |||
Anticorps gp91phox/CYBB/NOX2 (NL7) FITC | sc-130548 FITC | 200 µg/ml | $330.00 | |||
Anticorps gp91phox/CYBB/NOX2 (NL7) PE | sc-130548 PE | 200 µg/ml | $343.00 |