Date published: 2025-9-7

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Anticorps GAD-67 (A-4): sc-390383

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Fiches techniques
  • L'Anticorps GAD-67 (A-4) est un monoclonal de souris IgG3 κ, cité dans 2 publications, fourni en 200 µg/ml
  • spécifique d'un épitope situé entre les acides aminés 4-31 au niveau N-terminus de GAD-67 d'origine human
  • recommandé pour la détection de GAD-67 d'origine mouse, rat et human par WB, IP, IF et ELISA; également réactif avec d'autres espèces, dont bovine
  • Voir GAD-67 (F-6): sc-28376 pour d'autres anticorps conjugués GAD-67, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
  • m-IgG3 BP-HRP est le réactif de détection secondaire préféré pour GAD-67 Anticorps (A-4) pour les applications WB. Ce réactif est désormais proposé dans un ensemble avec GAD-67 Anticorps (A-4)(voir les informations de commande ci-dessous).

ACCÈS RAPIDE AUX LIENS

VOIR ÉGALEMENT...

There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (g-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67, the predominant GAD-67 form and the minor GAD-25 form. GAD-25 is not expressed in brain but can be found in a variety of endocrine tissues.

Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

Informations pour la commande

Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

Anticorps GAD-67 (A-4)

sc-390383
200 µg/ml
$316.00

GAD-67 (A-4): m-IgG3 BP-HRP Kit

sc-550478
200 µg Ab; 40 µg BP
$354.00

GAD-67 (A-4) peptide neutralisant

sc-390383 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-390383 P appropriate for?

Posée par: jerojero
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Répondue par: Technical Support
Date de publication: 2017-02-24
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Rated 5 de 5 de par Nice productThe GAD-67 Antibody (A-4): sc-390383 works well for Western blotting applications, showing strong signal with minimal background.
Date de publication: 2017-02-09
Rated 5 de 5 de par Satisfactory Western blot data of GADSatisfactory Western blot data of GAD-67 expression in non-transfected and human GAD-67 transfected 293T whole cell lysates and mouse brain tissue extract . -SCBT QC
Date de publication: 2013-12-27
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Anticorps GAD-67 (A-4) est évalué 5.0 de 5 de 2.
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