Anticorps GAD-65 (61/8F9): sc-130569
- L'anticorps GAD-65 61/8F9 est un monoclonal IgG1 de souris fourni en 200 µg/ml
- soulevée contre la pleine longueur de GAD-65 recombinante d'origine human, avec cartographie de l'épitope aux acides aminés 4-17
- recommandé pour la détection de GAD-65 d'origine mouse, rat et human par WB, IP et IF; non cross-reactif avec GAD-67
- Voir GAD-65 (A-3): sc-377145 pour d'autres anticorps conjugués GAD-65, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire GAD-65 (61/8F9). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67, the predominant GAD-67 form and the minor GAD-25 form. GAD-25 is not expressed in brain but can be found in a variety of endocrine tissues.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps GAD-65 (61/8F9) | sc-130569 | 200 µg/ml | $316.00 |