ACCÈS RAPIDE AUX LIENS
The Gab (GRB2-associated binder)/DOS ('Daughter of Sevenless') (Gab) family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs. Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur. This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins. The recruitment of signaling partners to Gab family members is phosphorylation dependent. Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus. The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Gab 3 (G-3) | sc-271476 | 200 µg/ml | $316.00 | |||
Gab 3 (G-3): m-IgG Fc BP-HRP Kit | sc-537644 | 200 µg Ab; 10 µg BP | $354.00 | |||
Gab 3 (G-3): m-IgGκ BP-HRP Kit | sc-534975 | 200 µg Ab; 40 µg BP | $354.00 | |||
Gab 3 (G-3): m-IgG1 BP-HRP Kit | sc-545279 | 200 µg Ab; 20 µg BP | $354.00 |