G-CSFR Antibody (F-11): sc-393698

G-CSFR Antibody (F-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects G-CSFR of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). G-CSFR (F-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The granulocyte colony-stimulating factor receptor (G-CSFR) plays a crucial role in hematopoiesis by mediating the effects of granulocyte colony-stimulating factor (G-CSF), which is essential for the proliferation and differentiation of neutrophil precursors in the bone marrow. G-CSFR is primarily located on the surface of hematopoietic cells, and proper functioning is vital for maintaining normal immune responses and combating infections. Upon binding with G-CSF, G-CSFR forms homodimeric complexes, which is a unique feature among hematopoietic receptors that typically form heteromeric complexes. Additionally, G-CSFR undergoes alternative splicing, resulting in distinct variants, including a soluble form that can modulate G-CSF signaling in the extracellular environment. Understanding G-CSFR structure and function is important for developing therapeutic strategies targeting this receptor in various hematological disorders and conditions characterized by neutrophil dysregulation.

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G-CSFR Antibody (F-11) References:

1. Cytokine receptors and signal transduction.  |  Miyajima, A., et al. 1992. Annu Rev Immunol. 10: 295-331. PMID: 1590989
2. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo.  |  Saito, M., et al. 1992. J Immunol. 148: 4066-71. PMID: 1602143
3. Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.  |  Fukunaga, R., et al. 1990. Proc Natl Acad Sci U S A. 87: 8702-6. PMID: 1701053
4. Activation of mitogen-activated protein kinase pathways by the granulocyte colony-stimulating factor receptor: mechanisms and functional consequences.  |  Kendrick, TS. and Bogoyevitch, MA. 2007. Front Biosci. 12: 591-607. PMID: 17127320
5. Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.  |  Larsen, A., et al. 1990. J Exp Med. 172: 1559-70. PMID: 2147944
6. A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain.  |  Bazan, JF. 1989. Biochem Biophys Res Commun. 164: 788-95. PMID: 2554900
7. Regulation of granulocyte colony-stimulating factor receptor-mediated granulocytic differentiation by C-mannosylation.  |  Otani, K., et al. 2018. Biochem Biophys Res Commun. 498: 466-472. PMID: 29501745
8. Ligand binding domain of granulocyte colony-stimulating factor receptor.  |  Hiraoka, O., et al. 1994. J Biol Chem. 269: 22412-9. PMID: 7520915
9. A point mutation in the granulocyte colony-stimulating factor receptor (G-CSF-R) gene in a case of acute myeloid leukemia results in the overexpression of a novel G-CSF-R isoform.  |  Dong, F., et al. 1995. Blood. 85: 902-11. PMID: 7531515
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11. Granulocyte colony-stimulating factor receptor and its related receptors.  |  Nagata, S. and Fukunaga, R. 1993. Growth Factors. 8: 99-107. PMID: 8385471
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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G-CSFR Antibody (F-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-G-CSFR Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G-CSFR Antibody (F-11) Specifications

Alternate Product Name: G-CSFR

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 25-200

Epitope Target: G-CSFR

Epitope Species: human

Product Reactivity/Detection: G-CSFR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for G-CSFR Antibody (F-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin