ACCÈS RAPIDE AUX LIENS
The Dim protein family consists of two classes, Dim1 and Dim2, which share a common thioredoxin-like fold, but most likely function in different biological pathways. Dim1, also known as TXNL4A (Thioredoxin-like protein 4A) or Spliceosomal U5 snRNP-specific 15 kDa protein, is a 142 amino acid protein that plays an essential role in pre-mRNA splicing. Due to a failure to express early zygotic transcripts, deletion of the gene encoding Dim1 in Schizosaccharomyces pombe leads to embryonal lethality during gastrulation. Since Dim1 shows sensitivity to a microtubule destabilizing drug, thiabendazole, it also may play a role in the formation of the mitotic spindle. This evidence demonstrates that Dim1 is essential for G2/M progression of the cell cycle and chromosomal segregation during mitosis. Localized to the nucleus, Dim1 interacts with hnRNP F, hnRNP H2, Cas-L and PQBP-1 to effect gene expression.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Dim1 (B-9) | sc-390839 | 200 µg/ml | $316.00 | |||
Dim1 (B-9): m-IgG Fc BP-HRP Kit | sc-540864 | 200 µg Ab; 10 µg BP | $354.00 |