Desmin Antibody (10H7D2): sc-65983

Desmin Antibody (10H7D2) is a mouse monoclonal IgG1 antibody that detects Desmin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Desmin is a crucial intermediate filament protein that plays a vital role in maintaining the structural integrity and function of muscle cells. Anti-Desmin antibody (10H7D2) recognizes protein located near the Z line in sarcomeres, where Desmin forms a network connecting adjacent myofibrils, facilitating the transmission of mechanical forces during muscle contraction. This structural organization is essential for muscle function, ensuring contractile elements of muscle fibers work in a coordinated manner. Desmin′s interactions with other proteins, such as dystrophin and various membrane-associated proteins, are critical for stability and integrity of muscle cell architecture. Mutations in the gene encoding Desmin can lead to severe muscle disorders, including adult-onset skeletal myopathy, highlighting Desmin′s importance in muscle health and disease. Desmin monoclonal antibody (10H7D2) serves as an invaluable tool for researchers studying muscle biology and related pathologies, providing insights into Desmin′s role in both normal physiology and disease states.

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Desmin Antibody (10H7D2) References:

1. The desmin network is a determinant of the cytoplasmic stiffness of myoblasts.  |  Charrier, EE., et al. 2018. Biol Cell. 110: 77-90. PMID: 29388701
2. Molecular insights into cardiomyopathies associated with desmin (DES) mutations.  |  Brodehl, A., et al. 2018. Biophys Rev. 10: 983-1006. PMID: 29926427
3. Desmin deficiency is not sufficient to prevent corneal fibrosis.  |  Pietraszkiewicz, A., et al. 2019. Exp Eye Res. 180: 155-163. PMID: 30590024
4. Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers.  |  Kedia, N., et al. 2019. Proc Natl Acad Sci U S A. 116: 16835-16840. PMID: 31371504
5. Desmin mutations result in mitochondrial dysfunction regardless of their aggregation properties.  |  Smolina, N., et al. 2020. Biochim Biophys Acta Mol Basis Dis. 1866: 165745. PMID: 32105824
6. Selective association of desmin intermediate filaments with a phospholipid layer in droplets.  |  Murakami, K., et al. 2021. Biochem Biophys Res Commun. 555: 109-114. PMID: 33813269
7. Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure.  |  Cao, J., et al. 2021. Evid Based Complement Alternat Med. 2021: 6621132. PMID: 34285704
8. Desmin as molecular chaperone for myofibrillar degradation during freeze-thaw cycles.  |  Ali, S., et al. 2022. Food Chem. 386: 132691. PMID: 35339085
9. Deep Characterization of a Greek Patient with Desmin-Related Myofibrillar Myopathy and Cardiomyopathy.  |  Papadopoulos, C., et al. 2023. Int J Mol Sci. 24: PMID: 37446359
10. Desmin Reorganization by Stimuli Inducing Oxidative Stress and Electrophiles: Role of Its Single Cysteine Residue.  |  Moneo-Corcuera, D., et al. 2023. Antioxidants (Basel). 12: PMID: 37760006

The preferred Desmin antibody is Desmin Antibody (RD301): sc-23879.