CYP1A2 Antibody (D-3): sc-393783
- CYP1A2 Antibody (D-3) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 246-315 mapping within an internal region of CYP1A2 of human origin
- recommended for detection of CYP1A2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for CYP1A2 Antibody (D-3) for WB and IHC(P) applications. This reagent is now offered in a bundle with CYP1A2 Antibody (D-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
CYP1A2 Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects CYP1A2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CYP1A2, also known as Cytochrome P450 1A2, is a crucial heme-thiolate monooxygenase enzyme that plays a significant role in the NADPH-dependent electron transport pathway within liver microsomes. This enzyme is essential for the oxidation of fatty acids, steroids, and xenobiotics, contributing to the metabolism of various drugs such as imipramine, propranol, and clozapine. Notably, CYP1A2 is localized to the membrane of the endoplasmic reticulum, a critical site for drug metabolism, which underscores its importance in pharmacokinetics and toxicology. The enzyme′s activity can be influenced by several factors, including induction by compounds like 3-methylcholanthrene and hyperforin, as well as inhibition by substances such as caffeine and fluoroquinolone antibiotics. Furthermore, CYP1A2′s involvement in estrogen metabolism has been linked to a reduced risk of breast cancer, highlighting its potential significance in cancer research and therapeutic strategies. Anti-CYP1A2 antibody (D-3) is an invaluable tool for researchers studying drug metabolism and related pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP1A2 Antibody (D-3) | sc-393783 | 200 µg/ml | $322.00 | |||
CYP1A2 Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-524089 | 200 µg Ab, 40 µg BP | $361.00 |