Cortisol Antibody (CORT-2): sc-51841

Cortisol Antibody (CORT-2) is a mouse monoclonal IgG3 antibody that detects cortisol in human samples through enzyme-linked immunosorbent assay (ELISA). Cortisol, the most potent glucocorticoid produced by the human adrenal cortex, plays a crucial role in the body′s response to stress by modulating various physiological processes. Cortisol is synthesized from cholesterol, with production stimulated by pituitary adrenocorticotropic hormone (ACTH), which is regulated by corticotropin-releasing factor (CRF). The intricate balance of cortisol levels is maintained through a negative feedback loop, where elevated cortisol inhibits ACTH and CRF secretion. In the bloodstream, cortisol predominantly binds to corticosteroid binding globulin (CBG), also known as transcotin, which facilitates transport and bioavailability. Once inside target cells, cortisol exerts effects by binding to specific intracellular receptors, leading to biological responses that include increasing blood pressure and blood sugar levels while simultaneously suppressing immune function. Anti-cortisol antibody (CORT-2) is essential for researchers studying cortisol dynamics in various physiological and pathological conditions, providing valuable insights into stress response and metabolic regulation.

The preferred Cortisol antibody is Cortisol Antibody (CORT-1): sc-51840.