The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs) and are required for the formation of these bodies. During HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins. CHMP5 interacts directly with LIP5, a protein re-quired for HIV release. Depletion of LIP5 will reduce HIV-1 budding, where-as a depletion of CHMP5 will increase HIV-1 release. Subsequently, over-expression of CHMP5 will reduce HIV-1 budding. CHMP5 also regulates late endosomal development downstream of MVB formation and a loss of CHMP5 will result in increased signal transduction due to a decrease in lysosomal degradation function.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps CHMP5 (D-11) | sc-374337 | 200 µg/ml | $316.00 | |||
CHMP5 (D-11): m-IgG Fc BP-HRP Kit | sc-540439 | 200 µg Ab; 10 µg BP | $354.00 | |||
CHMP5 (D-11): m-IgG1 BP-HRP Kit | sc-542122 | 200 µg Ab; 20 µg BP | $354.00 |